Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations
192,573
Published 2017-12-06
NOTE: In the video, I misspoke and said that Beta catenin enters the "mitochondria" - I meant to say it enters the nucleus. Sorry about the confusion everyone. Hope you find the video helpful :)
Hey everyone, here is another biomedical lesson, and this one is on the canonical Wnt signaling pathway. In this lesson, you will be introduced to the Wnt signaling pathway, and the purpose of the Wnt pathway. You will also learn the signaling pathway in a step-by-step fashion, starting with how the Wnt/β-Catenin signaling pathway is regulated during inactivation, how cellular beta catenin levels are regulated by the destruction complex, and how the pathway can become activated by the extracellular signaling Wnt proteins, which are growth stimulatory factors. Finally, you will learn what happens when the APC protein in the destruction complex is mutated, leading to inappropriate activation of the Wnt signaling pathway.
If you found this video helpful, please like and subscribe for more videos :)
JJ
Subscribe for more free medical lessons / @jjmedicine
-------------------------------------------------------------------------------------------------------------
Try Audible and Get A Free Audiobook
www.amazon.com/dp/B00NB86OYE/?_encoding=UTF8&ref_=…
For books and more information on these topics
www.amazon.com/shop/jjmedicine
Please help support this channel and future lessons by becoming a patron (and get cool stuff) ➜ www.patreon.com/jjmedicine
Follow me on Twitter! ➜ twitter.com/JJ_Medicine
Come join me on Facebook! ➜ www.facebook.com/JJ-Medicine-100642648161192/
Check out the best tool to help grow your YouTube channel (it’s helped me!)
www.tubebuddy.com/jjmedicine
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
• Medical Terminology - The Basics - Le...
Fatty Acid Synthesis Pathway:
• Fatty Acid Synthesis Pathway: Overvie...
Wnt/B Catenin Signaling Pathway:
• Wnt/β-Catenin Signaling Pathway | Ove...
Upper vs. Lower Motor Neuron Lesions:
• Upper and Lower Motor Neuron Lesions ...
Lesson on the Purine Synthesis and Salvage Pathway:
• Purine Synthesis and Salvage Pathway
Gastrulation | Formation of Germ Layers:
• Gastrulation | Formation of Germ Laye...
Introductory lesson on Autophagy (Macroautophagy):
• Autophagy | Macroautophagy & Importan...
Infectious Disease Playlist
• Infectious Diseases
Dermatology Playlist
• Dermatology
Pharmacology Playlist
• Pharmacology
Hematology Playlist
• Hematology
Rheumatology Playlist
• Rheumatology
Endocrinology Playlist
• Endocrinology
Nephrology Playlist
• Nephrology
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
All Comments (21)
-
Hey everyone! At 4:12 in the video, I misspoke and said that beta catenin "translocates into the mitochondria". I'm not sure why I said that, but I meant to say "translocates into the NUCLEUS". Sorry for the confusion. I hope you all found this video helpful though! :)
-
great video, incredibly clear, if only some of my lectures were like this
-
Fantastic, crystal-clear explanation. Extremely helpful.
-
wow, great vid! thanks so much man, have an assignment just about this! Made it very clear, and gave me a ground level understanding of it!
-
Exactly what I hoped for. Thank you for your excellent explanation.
-
i spent 2 hrs trying to understand this from my med school lectures, and you just explained it clearly in a few min🤯🤯
-
This was very helpful background information for my research on podoplanin. Thank you for the clear explanation.
-
Concise and clear information in such a short time for layperson like me.
-
wow, this was soooo good, thank you, you've got a gift for teaching!
-
SO HELPFUL, wish had found these videos before
-
This video is really helpful and easy to understand. Thanks for helping us :)
-
This video is very good as a description of the canonical Wnt pathway and how Wnt binding at Fz leads to increased transcription of certain genes. However, there are some issues with the description of Wnt family and the depiction of the destruction complex disassembly is shown incorrectly.
-
Thanks for sharing your knowledge. Helped me a lot.
-
Excellent video. Thank you
-
Made so simple and easy! Thanks!!
-
Thank you for this very good explanation.
-
I’ve got a expo of this tomorrow with drawings by hand, you just saved me.
-
HEY! THANKS A LOT. I'm an electrical engineering student in a struggle to undestand this pathway, and your video was awesome. Because, it was SHORT, and COMPLETE. Thanks really. Some advice tho, please share your references and books for further reading. And please keep doing this kind of videos, specially for people who are not studying health related majors :3
-
Great video, May I ask this Q: in invasive lobular carcinoma we lack E-cadherin and as Beta-catenin binds to E-cadherin is pathogenesis has to do smt with WNT pathway or just cell-cell adhesion?
-
you are amazing! thank you so much!
