Notch Signaling Pathway | Purpose and Mechanism

Lesson on the Notch Signaling Pathway. The Notch signaling pathway is a highly conserved and critically important pathway in homeostasis and the development of sensory hair cells and branched arterial networks. The Notch signaling pathway derives its name from the NOTCH receptors, which are activated through ligands located on the cell membrane of other cells (sending cells). The NOTCH receptor is composed of three domains, the extracellular domain, a single transmembrane domain, and a notch intracellular domain (NICD). Upon ligand binding to the Notch receptor, the Notch receptor undergoes cleavage reactions, releasing the NICD into the cytosol. The NICD binds to the complex of proteins, which translocate into the nucleus and activate Notch target genes involved in cellular proliferation, differentiation and apoptosis.

Hey everyone! Here is a lesson on the Notch signaling pathway. In this lesson, you learn what the Notch signaling pathway is, why it is important in development and homeostasis, what ligands activate the Notch receptors and the Notch signaling pathway, and how the Notch pathway leads to the expression of Notch target genes.

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