STUDY: Animal-Based Keto vs Low-Fat Plant-Based (Vegan) Diets for 28 Days. with Kevin Hall.

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Published 2023-04-17
What happens to your body in 14 days on keto versus 14 days on low-fat plant-based (vegan) diets?

PAPERS:

Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake by Kevin Hall
www.nature.com/articles/s41591-020-01209-1

Ad libitum meal energy intake is positively influenced by energy density, eating rate and hyper-palatable food across four dietary patterns by Tera Fazzino
www.nature.com/articles/s43016-022-00688-4

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium
www.thelancet.com/journals/lancet/article/PIIS0140…

Apolipoprotein B: An essential cholesterol metric for atherosclerotic cardiovascular disease
academic.oup.com/ajhp/article-abstract/80/2/83/674…

Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet by Iris Shai
www.nejm.org/doi/full/10.1056/nejmoa0708681

Why I quit the keto diet by Drew Harrisberg
www.forksoverknives.com/print/print.php?id=83672

BOOKS:

Brain Food: The Surprising Science of Eating for Cognitive Power by Lisa Mosconi, PhD
www.amazon.com/Brain-Food-Lisa-Mosconi-PhD-audiobo…

Burn: New Research Blows the Lid Off How We Really Burn Calories, Lose Weight, and Stay Healthy by Herman Pontzer PhD
www.amazon.com/Burn-Research-Really-Calories-Healt…

Don't Be Such a Scientist, Second Edition: Talking Substance in an Age of Style by Dr. Randy Olson PhD
www.amazon.com/Dont-Such-Scientist-Second-Substanc…

YOUTUBE EPISODES:

Dr Sten Ekberg gets fact-checked by MD PhD Doctor, by Gil Carvalho
   • Dr Sten Ekberg gets fact-checked by M...  

I Ate 100 EGGS In 7 Days: Here's What Happened To My CHOLESTEROL by Sten Ekberg
   • I Ate 100 EGGS In 7 Days: Here's What...  

I ate 900 Eggs in 30 days. This is what happened to my body by What I’ve Learned
   • Why I'm eating 30 eggs a day  

I ate 50 sticks of butter in 1 month (here's what happened..) by Steak and Butter Gal
   • I ate 50 sticks of butter in 1 month ...  

I ate Raw MILK and EGGS (ONLY) for 30 days (What happened to my BIOMARKERS?) by Rob Stuart
   • I ate Raw MILK and EGGS (ONLY) for 30...  

From Paleo To Keto To A Plant-Based Diet | Drew Harrisberg
theproof.com/why-i-quit-keto-with-drew-harrisberg/

0:00 Overdosing on eggs
0:51 Keto vs vegan
3:14 The paper
4:44 Satiation vs satiety
7:39 Calorie consumption
9:10 Weight loss
10:37 Cholesterol
13:23 Blood sugar
16:01 Keto and longevity
18:07 Long term keto studies
19:21 Which diet is better?
20:55 Continuous glucose monitors
21:36 Carbohydrate insulin hypothesis

All Comments (21)
  • "Do you have time for an 8 hour episode?". Chris, if you made 8 hours of content, and it was half as engaging as this presentation, I would gobble all 8 hours!
  • I just got back home from holiday. I went from 192 to 201 lbs. Which is about the same, so I'm real happy about that 😊
  • @ChicoDaUno
    "So my total cholesterol went from 207-277.' So that is about the same ." He said that with a straight face & all. Clearly, he missed his calling. Should've been a politician instead .
  • @villetakoo
    "My total cholesterol went from 207 to 277 which is about the same." 🤣 I laughed out loud so hard after this. How can these guys be this out of touch with reality? Well, whatever you have to do to stick to your untruthful views of reality.. 🤷‍♂
  • @Physionic
    Just at the beginning, but when I heard total cholesterol of 277 is the same as 207 I literally exclaimed, “WHAT!?” and then when I heard 136 to 201, I exclaimed, “IN WHAT WORLD!?”. EDIT: Made it further into the video - super interesting, especially considering my latest video on hunger and keto. I’ll need to look over the data again!
  • @scotmcpherson
    This ignores the studies published by the acc, Ada, and aha, showing that high serum cholesterol and dietary saturated fat are not good indicators of health risk. ApoB IS, and LDLs and apob are NOT similar.
  • @musyclover
    This is one of the best channels on YouTube. The production is excellent. The way you weave the info together and correct mistakes as you find them. It’s a 10 from me. 🤩
  • @jmm3688
    Your humor, editing are amazing !!! Please, please if possible make a health documentary!! It’s your calling!! At least a 30 minute long series. Please!!
  • As a 2 1/2 year carnivore it took me a good 3 to 6 months to become fully fat adapted and my ketone levels stayed high so I’m pretty sure that my clear brain zero brain fog depression and anxiety gone are benefiting me on a ketogenic diet.
  • 😮 since when is a 48% increase (LDL from 136 to 201) staying the same??
  • @Curioinfinity
    When he said his numbers were the same (after eating those eggs) I was drinking tea and I have never been closer to doing a spit take in my life. We need spit take warnings!!! But seriously… completely nuts! Thank you for the videos! You and Dr Gil are my favorite go-to nutrition channels. You are very entertaining and yet scientific, who knew that was even possible!
  • @MissMetaBlack
    Im no doctor, but I'm pretty sure 207 isnt the same as 277...
  • @Joseph1NJ
    I didn't know this either: "Satiety and satiation are related terms that are often used interchangeably, but they actually refer to different aspects of the feeling of fullness and satisfaction after eating. Satiety refers to the feeling of fullness and satisfaction that persists after a meal and suppresses hunger and the desire to eat again. It is a longer-term feeling that relates to the overall energy balance of the body and can last for several hours after a meal. Satiation, on the other hand, refers to the feeling of fullness and satisfaction that occurs during a meal and signals the end of eating. It is a shorter-term feeling that relates to the immediate sensory experience of eating, such as the taste and texture of food. In summary, satiation is the feeling of fullness and satisfaction during a meal that makes you stop eating, while satiety is the feeling of fullness and satisfaction after a meal that helps you maintain a healthy energy balance by reducing hunger and the desire to eat." (From ChatGPT)
  • @Alex-qb2es
    The backgrounds, your family members, the interviewed experts, and especially the video content are always so entertaining, great job! I've never seen a cooler grandpa and YouTuber, thanks so much for another awesome video, Chris! 🌱
  • @andyb1322
    Thank you for your content! This video came up on my YouTube recommendations, and the timing of it was perfect. I was 2 days into my latest low carb diet run and watching your videos convinced me to give it up. So instead cooking up bacon and eggs this morning, it's steel cut oatmeal and wild blueberries. While I thought a high carb low fat diet was probably healthier for me, I could never get my mind to fully commit to the diet. But the way you structured and edited your videos really helped me believe your message over all the videos i've seen promoting keto / low carb diets. Great video -- love the editing and the length and depth of and information shared!!
  • (I don't promote ketogenic diets or very low carb diets. Hypocaloric diets with low inflammatory agents tend to reduce insulin exposure and A1C fastest regardless of the macro breakdown). Glucose tolerance tests are contraindicated as diagnostic for people who have been on a low carb diet because glycolytic enzyme synthesis is suppressed when insulin levels are chronically low. In addition, the muscles load with free fatty acids in lieu of some glycogen, so the muscle cells remain "loaded" and there is less room to take on glucose, in addition to the pancreatic response to glucose being blunted (as the doctor indicated). We KNOW however that low insulin exposure reduces the disposal of glucose at the cellular level because emerging type 1 diabetics often have a reduction in insulin needs after a few weeks of insulin therapy. I mean we absolutely know that newly diagnosed type 1 diabetics HAVE glucose in their muscle cells, but aren't burning them. In a hypocaloric situation, ketogenic diets don't produce as profound a spike with a glucose tolerance test. It has been shown to reverse within 2-3 days of eating over 25% carbs. Insulin actually increases insulin sensitivity in the short term by stimulating synthesis of glycolytic enzymes. Keep in mind that while high glucose levels (140+) can destroy beta cells, insulin exposure is regarded by researchers as the primary mechanism of the development of insulin resistance at the cellular level. The pancreas' ability to produce and release insulin is not equivalent to insulin resistance but is often misinterpreted as being so. Here's the problem. Work with type 1 diabetics have shown that on a per carb gram basis, starches that have low GI, like al dente pasta and legumes actually require 150-200% as much insulin to manage over an extended period of time of 8-12 hours. The rise in glucose is very slow, but much of the glucose from those carbs is released and absorbed in a very delayed fashion as the fiber and intrinsic proteins are broken down, and it appears that there may even be sensors in the large intestine that sense the presence of "bulk" or stretch, and trigger the pancreas to release glucagon which raises blood sugar, and requires extra insulin to counteract. There is no doubt that high gluten pasta requires more insulin on a carb gram basis than carbs with less fiber and associated proteins. The gluten forms a gelatinous covering around starch granules that causes the delay and also the glucagon release signal. Harvard has confirmed this with high gluten wheat products. (I wanted to add that excessive fructose gets turned into liver fats which can make the liver insulin resistant, and fructose (and alcohol) also yields uric acid that also causes insulin resistance so basically you have three options for carbs: 1) Fructose yielding sugars-see Uric acid and fatty liver. 2) Slow digesting glucose polymers like beans and some grains which provoke glucagon release, demanding more insulin to manage and 3) Easily digested glucose polymers like rice, potato and yams and a few other sources like plantain and tapioca that don't provoke gut irritation leading to glucagon release or possibly other mechanisms of spiking blood sugar in a delayed fashion, however, these starches provoke a fast increase in blood sugar that may be above the euglycemic range. This can be blunted by combining with cellulose and resistant starch, protein and fat, or by consuming around activity. I've seen people drink 75 grams of glucose polymers during a 1 hour workout and not had their blood sugar go much over 100.
  • Ive just recently started eating 2 good meals a day within about 7 to 8 hours. Lots of fresh veggies, spuds, chicken & fish & some fruit each day. Occasionally bread & rice & pasta, but not huge amounts. kind of everything in moderation. The BEST thing I did was make 2 rules for myself. No added sugar to anything I eat and, stop eating at 7pm. Nada. Finish! No crap while I'm watching TV at night. I cook from scratch & use yummy olive & avocado oil with the odd knob of butter. It's a delicious healthy mediterranean, leaning diet with some milk & eggs some days. So far 8 kgs have just dropped off me. If I am truthful, the food that I am eating now is pretty close to what I ate before. I've always eaten good quality fruit, vegetables and nuts and high-fiber foods BUT I have decreased the amount I eat and now have a start & finish time and dont just endlessly graze and eat unnecessary calories. Also, get rid of sugar, It's unbelievably fattening
  • Really enjoyed this episode… so eye opening… I had no idea about the Inuit’s mutation , keto doctors reference them so much…..you are my hero ❤
  • My exam test scores in first exam is 87/100 and 42/100 in final exam. I told my mom nothing to worry about because its about the same. Love you Mom❤❤❤
  • Oh my, I'm biased in favor of keto (perhaps not decades uninterupted), but I have two points to make, which I think are free from that bias: 1) Keto doesn't always mean low fiber. The types of vegetables prefered on keto often have plenty of fiber. And if people bake then there is also for example psyllium, oat fiber and coconut flour. I ate more vegetables after I started keto than before, even though only a certain amount was allowed (I admit my eating habits before were poor). So while vegan low-fat surely wins over keto in terms of amount and variety of fiber, keto can contain enough fiber. 2) The calorie rich foods do make it easier to have a much higher intake when a person isn't counting their calories. And you even explain why. With the calorie (and fat) intake of the LC group, it's a proof that keto works, that they lost any body fat at all, when based on calories alone, they should have been gaining it. This excess intake also explains the blood tests results of this study. And elevated uric acid - how much meat were they consuming? Keto done right improves metabolic markers in the blood. Most people on keto, if they are on it to lose weight, DO watch their calories. And on keto the calorie restriction doesn't cause hunger, even if satiation isn't effective on it's own to keep the calories low or reasonable. Even if they stop counting, they DO know to keep the portions smaller. I think I remember seeing studies where the same calorie intakes on LC and LF diets were compared and then keto WAS the more effective option for losing body fat. PS: Which group enjoyed their food more? That's also important for a sustainable nutrition style.