Heme Catabolism and Degradation Pathway - Biochemistry Lesson

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Published 2017-01-15

Video lesson on catabolism and degradation of heme from hemoglobin during red blood cell (erythrocyte) hemolysis in a powerpoint, university-styled lecture!

Hey guys! In this video I (attempt to) simplify and explain the heme catabolism pathway in a (hopefully easy) step-by-step lesson! I first start by explaining basics of the physiology and function of a red blood cell (aka erythrocyte) and that hemoglobin is released from red blood cells during degradation or hemolysis. I next explain hemoglobin is taken up by the reticuloendothelial system (white blood cells like macrophages) and converted to heme. Heme is then converted to biliverdin and then bilirubin, and the iron moiety of heme is stored in ferritin and hemosiderin in white blood cells. From here I explain step-by-step bilirubin metabolism in liver hepatocytes, conjugation and incorporation into bile in the gallbladder, conversion to urobilinogen and stercobilin and urobilin in the urine.

I also discuss the enzymes required for each step of the heme catabolism pathway.

At the end of the video, I also provide quick facts regarding erythrocytes, hemoglobin, and bilirubin and the clinical "standard" lab values of blood serum bilirubin.
If you find this video helpful, please like and subscribe for more lessons like this one!
JJ

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.

I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)

Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

@marihanbadr1271 5 years ago

this seamlessly summarized an hour long lecture. God bless you sir

@Soujyam 4 months ago

Ah. Such a relief. Learning biochemistry can't be more clearer than this.

@raphaelmalpica401 6 years ago

If you go to First Aid USMLE Step 1 and get to this section all I read was blah, blah, blah. But with you WOW!!! Thank you!!! You made it so much easier to understand. After 12 years practicing as a general surgeon in Mexico and now having to take my steps its not easy going back to basics. Gracias!