Insulin Sensitivity Is A Hallmark Of Longevity

Good video! Thanks! Waiting for the part 2.

Most excellent presentation. Thumbs Up!

Very interesting. Thanks!

Nice presentation. Thanks✌️

Thanks again Dr. caloric restriction or an intermittent fast, seems to not overwork the body. Helps to keep glucose levels down. Thanks again 👍👍👍

Excellent information

A studio was posted showing that the CR mice who were fed once per day did much better that CR mice who ate the same food, same calories but ate throughout the day. Same food, same calories. …. Showing that it was the fasting that created greater health and life span.

The concept of insulin resistance is not well understood and emerging research shows that insulin sensitivity can vary from tissue to tissue during a fast and depending on an individual's macro ratio. For example a low carb I.F. individual can expect to have some peripheral or muscular insulin resistance which is thought to be a temporary effect that may even be beneficial. I think it is also interesting to look at insulin sensitivity in relation to circadian rhythm and how this changes over time. A really interesting field. Anyway, thank you for sharing today's video. I always look forward to your videos and your responses to comments

This begs the question on if the long lived low insulin folks achieved this outcome through genetics, diet, exercise or some combination

Excellent!

Uh hello Dr. L, Could you still remember about the 8 am 1pm time window of eating video you did? I lost sight of it and have watched too many of your videos to know which it is.

What would be the ideal blood glucose or hgA1c for anti aging based on your research? Dr Perlmutter shared some research a while ago on brain atrophy at blood sugar suggesting the lower the better. Some suggest 3.3 for fasting and 4.6 for optimal when on a low carb diet

I certainly would not assume insulin sensitivity decreases in the very old. Surely it is more likely those who get really old know how to stay healthy? It is actually very simple. The information required is available for most people, but apparently never for medical doctors. A video explaining how each of us on our own can avoid getting diabetes, or any of the deseases of affluence, would be more useful, but since you never explained why insulin sensitivity is created anyone looking for useful information has to look elsewhere.

Please produce a video on leptin , lifespan etc. see Ivor Cummins Ron Rosdale MD interview.

Doc, what are the best ways to measure insulin sensitivity? I've had my C-peptide tested several times, which is an insulin proxy, and it's always on the lower end of the normal range. I've test my A1C several times as well, never had a measurement over 4.9.

Is the centenarian's reduced insulin sensitivity a result of less circulating growth hormone in them (or maybe less growth hormone receptor sensitivity due to genetics) or because of eating less than people that didn't live that long.

Thanks Michael - a bit off topic, I’m a bit confused about the relationship between TMG and methionine. I want to keep my methionine low for longevity but I’m also thinking of taking TMG to keep methyl groups in balance while taking NR to test if it improves liver markers.

What was especially interesting to me was the increased lifespan from the growth hormone knockout mice. I always thought growth hormone was beneficial-- it's often touted as a benefit of fasting.

Thanks! Did you find the optimal range of insulin and homo-ir levels w.r.t ACM? For H1ABC which is in %, for the time being I was thinking of deriving it based on glucose reference of 80-94 mg/dL. If H1ABC is between ~4.4-4.9% it means that on average over the past ~3months the glucose levels was 80-94 mg/dL. If I am interpreting it correctly.

Are there any studies exploring if HOMA is a better predictor of all cause mortality than fasting glucose?