Kidney Function Declines During Aging-Can It Be Reversed?

I was diagnosed with stage III kidney disease about 5 years ago and I went to a low fat whole food plant based diet. My eGFR is >90 and no sign of kidney issues. No animal products including dairy, no processed refined fats (no oils) and no processed refined carbs other than a little high fiber bread or crackers from time to time. I also turned around my erectile disfunction, cardio vascular disease, neuropathy, and diabetic retinopathy....yes I was almost blind in my right eye and now I see with only a little bit of noise in my vision and it is still clearing, finally my insulin use is down to 15 units/day using only a basil insulin, way down from over 50 units a day. At 60 years old I have turned my health completely around and I feel like a kid again!!!! Low fat whole food plant based diet is the key! BTW....Great video! I love your work!

Awesome video! I’be been tracking everything I eat for a week and am getting my first blood test tomorrow morning. A journey of a thousand miles begins with a single step. Thanks!

My mother missed being 95 by three weeks, killed by bedsore due to nursing home neglect. Texas governor Abbott banned family members from visiting; absent that she might still be alive; I had her on carnosine. She never had any known kidney issue.

High-protein diet with renal hyperfiltration is associated with rapid decline rate of renal function: a community-based prospective cohort study "Conclusions A high-protein diet increases the risk of RHF and a rapid renal function decline in the general population. These findings suggest that a high-protein diet has a deleterious effect on renal function in the general population."

I've watched a bunch of your videos and I think they're great! Thank you so much for putting this info out there.💪😁👍

I’m 62. My eGFR is 105. My diet is low fat unprocessed vegetables and fruit only

Very useful information and very well presented. Many thanks.

Thank you for these videos. Well presented and very pertinent.

Thanks Michael. You have taken lot of work to do this.

My eGFR varied widely from high 30’s to about 75. Doc sent me to kidney specialist who performed a few more tests and lots of questions. He said eGFR is not the be all and end all of determining kidney function. Some people have apparently low eGFR but normal kidney function. Apparently low function is normal in my family but most live into their 90’s. Red wine can increase eGFR.

Great explanation. Thank you.

Amazing content 😊

Dr, that one eGFR rating you got that was in the 60’s… really low. Technically stage 3 CKD. Do you remember what you were eating around that time to have driven your score so low? Great job raising your numbers and saving your health!

Thank you for your video, thank you for sharing thank you for taking the time to track everything so you could share it. Very informative really appreciate it.

Thanks very well done. Much useful information.

Great work! 8)

Thank you so much! You are the best ❤️❤️❤️

An extremenly interesting data analysis! I a curious, does your eGFR somehow corellate with an updated eGFR formula that you (or your lab) perhaps started to use from 2015 onwards? Or perhaps the lab switched to a standardized way of calculating the serum Creatinine? Did you use the same CKD-EPI formula and based your calculations on the Creatinine levels alone?

Thanks!

Choline is a semi essential nutrient. A number the foods you mention are high in Choline. While the body can manufacture some choline it doesn't manufacture enough. The rest of the choline needs of our body has to come from our food and and supplementation. The last review by the Institute of medicine of choline intake was done in 2018 and largely confirmed The Institute of medicine's food and nutrition recommendations from the late 1990s. According to these recommendations we are clearly not getting enough choline into our body. While there was clear evidence choline was necessary for the functioning of the liver, there has also been mention in the literature that choline is essential for kidney and many other functions in the human body. I urge you and your followers to research choline as it may be one of the overlooked supplements that reverses aging in the human body. People can't just rush out and buy a choline supplement because it has been associated with the increase in TMAO. TMAO is associated with Cardiovascular Disease. This increase in TMAO is related to the microbiome break down of choline by-products in the gut though it is clearly not fully understood. If you take antibiotics with choline TMAO is not produced and the choline is then distributed throughout the body including into the brain (which needs it to produce acetylcholine). The proper amount of choline does wonderful things to the body. For example the proper amount of choline reverses non alcoholic fatty liver disease which was thought to just be a symptom of Aging in older people. Choline deficiency may be related to sarcopenia and Frailty in that proper amounts of choline are necessary for the body to manufacture muscle cell membranes. I have not been able to document whether the body scavengers muscle cell membrane when it needs to produce choline and does not have enough available from our diet. It could be that as our muscle cells age and die the body cannot produce new ones because it doesn't have enough choline to manufacturer cell membranes for the new muscle tissue. Choline is necessary for the manufacture of cell membranes of virtually all of the cells of our body. There is a special set of statements issued by the Institute of medicine about choline and there are several review articles about choline. I believe that if you can consume choline and stop the side effect of the production of tmao you will see significant anti-aging effects throughout the body. You're increased function of your kidneys may be related to increased choline absorption from your diet.