Can we stop aging? | Andrei Gudkov | TEDxMorristown

TEDx Talks
TEDx Talks
142,219
0
2017-06-08に共有
Scientist and expert Dr. Andrei Gudkov tells us what aging really is, how and why it happens, and what our future might be. What is the key to longer, healthier lives, and is it in our reach?

Andrei is a preeminent cancer researcher, Senior Vice President for Basic Science; Chair of the Department of Cell Stress Biology, and a member of the senior leadership team for National Cancer Institute (NCI) Cancer Center Support Grant at Roswell Park Cancer Institute (RPCI). He is responsible for building on the basic and translational research strengths of the Cell Stress Biology program in DNA damage and repair, photodynamic therapy, thermal and hypoxic stress and immune modulation. Andrei was formerly at the Lerner Research Institute, Cleveland Clinic Foundation, where he served as Chair of the Department of Molecular Genetics and professor of biochemistry at Case Western Reserve University. He earned his doctoral degree in Experimental Oncology at the Cancer Research Center, USSR and a Doctorate of Science (D.Sci) in Molecular Biology at the Moscow State University, USSR. He has authored or co-authored 218 scientific articles, holds 54 patents and co-founded six biotech companies, including Everon Biosciences, Inc. that develops antiaging drugs.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
コメント (21)
  • @lunalunam1
    I love this presentation! Smart and with a great sense of humour!
  • @charlesdavid7762
    As noted, there are multiple causes of aging. The first is due to thermodynamics and the increase in entropy that occurs in a system that uses energy to process information. There are just a few states for a living cell while there are almost an infinite number of states of death and decay. The second is due to the accumulation of damage that occurs when there is no proper repair. The body is excellent at healing when provided the resources to do so, but most people do not provide the proper resources. The most important resource is pulsed nutrition with periods of feasting and fasting in synchrony with one's neuro-endocrine cycles. This allows the body to clean house via the cellular mechanism of autophagy while activation of the sirtuins in the presence of high levels of NAD+ facilitate DNA repair, including restoring the telomeres. The re-feeding/feasting phase activates the stem cells to rejuvenate damaged cells, like the immune system, brain, and muscles thereby preventing the onset of frailty, autoimmune disorders, inflammation, and dementia. Also, maintaining proper methylation of one's DNA prevents endogenous virii from activating and causing harm. Receiving blood transfusions or vaccinations that are contaminated with retrovirii can also activate those endogenous virii. While treatment with retro-viral agents such as those used for the treatment of HIV (AZT) might help to fight off any activated retrovirii, there is no evidence that it can perform the other tasks needed to prevent frailty and the steady progression to death. Sorry, but that is not the fountain of youth.
  • @johnkopf6816
    I like the ideas shared. It does seem like the start of of a scary movie where they wake up something in our DNA and it spreads.
  • @quinnjones1655
    Amazing what can happen when enterprising students have access to research grants ... \
  • @Coinpicker
    Aging cell damage sounds like effects of free-radicals.
  • @galtbarber2328
    If he is right (and I doubt it is so simple) then using genome editing tools to remove endogenous viruses in our junk dna would greatly expand the lifespan of many creatures.
  • @nz7921
    Who is here during the COVID-19 pandemic?
  • @vitaminboss
    Doesn't telomere shortening lead to DNA damage which leads to cell senescence?
  • @faismasterx
    I quickly read the title as, "Can we stop arguing?"
  • @jdtv50
    “There were no people born of the 19th century here today” The immortal dude in the room: adding that quote to list of coincidences since he’s present
  • @royzlatanestevez9843
    FIVE years ago and we are still aging. They will still be talking about "stopping aging" in 30 years (well, probably different people, because AGING) and nothing will change. AGING is a FACT of life.