Plasma Trigonelline: A Mediator For Dietary Trigonelline To Increase NAD? (8-Test Analysis)
Published 2024-06-26
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Paper referenced in the video:
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia www.nature.com/articles/s42255-024-00997-x
All Comments (19)
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Somewhat unrelated, but in past videos you've provided a breakdown of all the foods/amounts you eat per day (on average). It would be really nice to see a video that shows all the food put together in the meals you eat each day. Also, do your meals/food stay the same everyday (aside from cheat meals), or do you change things up on your two 90-min workout days by changing your meal timing or having a pre/post workout meal?
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Trigonellin supplement is expensive! But to be fair, so are NMN and NR. That’s why I take nicotinamide.
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seemed like a dissapointment the diet boost didnt translate to an NAD +ve result . But then a great switch up friend , drop in a trial looking at the effect supplemental trig .Super interested to see the result , absolutely got our attention now, tks
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Any further updates coming on oral microbiome optimization and the effects of vanillin?
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hm one still wonders what "the magical component(s)" of legumes is that give/s them the longevity outcomes 🤔 hopefully ur next trigonelline experiment helps figuring that out further
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Good try with the clover sprouts Mike. Italian clover I presume. If the supplement works, sakurajima radish should still be worth a go. Cheers!
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certainly worth trying a higher dose, but I wonder what average intake is and if your well above that carefully evaluating side effects would be important.
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What was the estimated dietary intake amount of trigoneline you were able to reach?
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quite excited now about the mega dose experiment, as high trigonelline is associated with incerased ACM. it is not clear however whether Trigonelline was accumulated due to deranged metabolism, or the the other way round. Will you measure he std phenoage profile as well? Or do you think that 10 days is too short to leave a dent? It is indeed an alkaloid, so you can expect AST to increase a bit.
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I'd imagine many of those nad points also have recent niacin intake, and with the long tail of nad decline relative to the upswing on supplementation, it's perhaps no surprise there is no obvious signal. Anyway I don't think NAD is that important relative to homocystiene and I'd test that first.
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Did you include in your diet white clover sprouts (Trifolium repens), red clover sprouts (Trifolium pratense), or a combination of both? Should one reasonably expect variation in trigonelline content between these types? I heard that red clover in particular can increase estrogen levels and progesterone (in women) due to their isoflavones content, but they can also have blood-thinning effects. On that note, are white clover sprouts generally preferable to red clover sprouts?
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Have you seen the latest update of the rejuvenation olympics?
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Well perhaps this is promising: Trigonelline is not responsible for the acute increase in plasma homocysteine following ingestion of instant coffee. Eur J Clin Nutrtion.
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Maybe I missed one of your mama but I thought niacin was doing a good job? Is methylated niacin supposed to be better?
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My main sources of Trigonelline is cold brewed green coffee and Daikon radish, mind sharing that Trigonelline supplement you mentioned ? All I could ever find was overpriced ground fenugreek pills 😅
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What's the advantage of this stuff over plain niacin? Even if it does increase NAD it's still vastly more expensive...
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Why not get NAD from niacin or tryptophan pathways? Just eating some meat would suffice
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You would get higher NAD if you workout out fasted .my channel is dedicated to that while useing advanced breathing techniques to be able to keep the intensity high. Im 49 this September. Instant coffee is high in Trigonelline so I do drink 2-3 cups before a work out.
