Plasma Metabolites Of A Healthy Lifestyle In Relation To Mortality And Longevity

Hey everyone, I made a mistake, and my apologies! CE 22:6 contains DHA, not EPA as shown in the video.

For me, modest drinking no longer works, if it ever did. Repeated testing, based on my Oura data and simply how I feel, shows that even moderate drinking negatively impacts my sleep, especially REM. Given that I'm older (69) and have suffered from sleep issues for over a decade, my self prescription is zero alcohol. Zero alcohol combined with no food within 3 hours of sleep significantly improves total sleep time as well as duration of deep and REM sleep.

Dr here. routinely look at labs. I really appreciate your quality evidence based presentation on the true comlexity of even a seemingly banal result like a serum triglyceride level . For instance i learnt today that TG esters levels do matter . All this detail is one more piece to the puzzle, tks

I took a break from longevity research and YT. Back now, looking forward to catching up on your excellent content. Glad to see I can swap annoying NMN for 60mg nicotinic acid.

Wealth has a big impact. Having access to good healthcare and dental care is crucial. Also air quality.

Kind of surprised that quality sleep was not one of the factors. Very interesting!

Hitherto life long Gin & Tonic man here . Unfortunately had to go Xmas and birthday only treat now due to underlying AFib . My own 24 hr ECG monitor would read from occ baseline atrial ectopic to about 6 or so an hour with occ couplet after a few G&Ts . Interestingly never got ventricular ectopics .Repeated the experiment many times unfortunately the same result. Great collection of Gins now sitting in my cupboard going to waste. Fear of stirring up my Afib keeps them there .

I wish this study also looked at irreversible metabolites which accumulate in the body forever and when the amount is great enough, interferes with mitochondrial function. Glucosepane is a known AGE (Advanced Glycation End-product) which results from excess Glucose in the blood (high-carb diet.) Lipofuscin Compounds appear to be the result of excess Unsaturated Fats (both Poly- and Mono-) in the blood. It is said that we need some minimum level of glucose and unsaturated fats (both Omega-3 and Omega-6, even though the latter is considered inflammatory) but no one agrees on what these minimum amounts are. I try not to be an absolutist so I eat some carbs (average somewhere between 50 to 100g/day) and I take a fish oil supplement (2.4 g/day) but no more than that. The idea of irreversible metabolites piling up like a landfill bothers me. 😊

As far as I remember DAGs are the fats which mechanically resist insulin in insulin resistance (blocking GLUT4)

Superb insights!

Thanks again. This quite entertaining tho' too old for it to be of benefit personally. I'm also impressed by how much you follow the literature for example your fenugreek intervention come at the threshold of this release: "Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia. Nature Metabolism, 2024"

Thanks!

Thank you for another thought provoking presentation. “Less unsaturated” is a double negative suggesting that saturated fat triglycerides code for longevity? The other curiosity was the 5-fruit portions per day. In one of your earlier study analyses presentations suggested that lowest ACM was associated with an intake only 1.5 portions of fruit per day. Both statements cannot be correct!

This is very interesting.

just rewatched it , the years of MV use as a component of AHEI score was to parapharase Sergeant Schulz , very interesting .

Very interesting video again, thanks! What is your take on rapamycin? And what about Matt Kaeberlein Optispan, he seems to follow your philosophy on being conservative on supplements.

what was your Kynurenine/Tryptophan on this test?

thank you very much for presenting that study. Good mental food on this cold Easter sunday :) For me, the most surprising part of it is about the unusual triacylglycerides >C56:3+ . They are strongly correlated, meaning you can have too little of them and having more is helpful for longevity. An article from 2012 "Very long-chain fatty acids: elongation, physiology and related disorders" does not mention them. Technically they are kind of waxes, but as waxes they are unusual as well. My guess is that they are related to the well-functioning of the endoplasmatic reticulum and the capability to produce sphingomyelins. I discussed the subject with Gemini and it mentioned: "The emerging information supports the possibility that these unusual TAGs play a role in organelle membrane structure and function, particularly in the ER and Golgi."

Is that DEXA scan mentioned near 16 months ago in the works? I am curious about the effects of reducing your calorie intake.

What about peptides and rapamycin or metformin? Why don’t you use these?