Thomas Seyfried: Cancer: A Metabolic Disease With Metabolic Solutions

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Published 2015-03-02
Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. Cancer is suppressed following transfer of the nucleus from the tumor cell to cytoplasm of normal cells containing normal mitochondria. These findings indicate that nuclear genetic abnormalities cannot be responsible for cancer despite commonly held beliefs in the cancer field. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria. Cancer growth and progression can be managed following a whole-body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies. This transition will reduce tumor vascularity and inflammation while enhancing tumor cell death. A novel “press-pulse” therapeutic strategy is in development for the non-toxic metabolic management of cancer. Malignant brain cancer in preclinical models and humans will be used to illustrate general concepts. As each individual is a unique metabolic entity, personalization of metabolic therapy as a broadbased cancer treatment strategy will require fine-tuning to match the therapy to an individual’s unique physiology.

Thomas N. Seyfried received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He did his undergraduate work at the University of New England, where he recently received the distinguished Alumni Achievement Award. He also holds a Master’s degree in Genetics from Illinois State University. Thomas Seyfried served with distinction in the United States Army’s First Cavalry Division during the Vietnam War and received numerous medals and commendations. He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine and then served on the faculty as an Assistant Professor in Neurology. Other awards and honors have come from such diverse organizations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, and the Ketogenic Diet Special Interest Group of the American Epilepsy Society. Dr. Seyfried previously served as Chair, Scientific Advisory Committee for the National Tay-Sachs and Allied Diseases Association and presently serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, the Journal of Lipid Research, and ASN Neuro, where he is a Senior Editor. Dr. Seyfried has over 150 peer-reviewed publications and is the author of the book “Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley Press).”

All Comments (21)
  • Thanks to Thomas, I followed him, I understood what he said and my Stage 4 Cancer DISAPPEARED !!!
  • @canceroutlaw
    As someone with an "untreatable" stage 4-b appendix cancer, let me say THANK YOU for all your work and witty explanations. You've just added another tool in my cancer fighting toolbelt, having to build a "standard of care" for myself to fight with natural medicines and nutrition. It's early on. Eight months ago oncologists said I have 6 months to live, but now the majority of my tumors and cancer cells are gone and I feel better in many ways than I did before all this began. Again, thank you.
  • @nyxs60
    I have worked on a cancer ward and I always wondered why people lost their appetite in cancer. Its the natural intuitive body at work ❤️
  • I am a veterinarian, and have been studying human and comparative nutrition since the 1970s. I have found that a high-fat, low-carb diet, combined with intermittent fasting, is the magic bullet for my insulin resistance. No more obesity, hypertension, and I am hoping no more issues with cancer. (Recovered from bladder and skin cancers.) Good vid.
  • @SR-zu9pn
    Would take my daughter to the Children's Hospital to play her harp around Christmas and other times. Was shocked beyond belief to see the kids served 'jello (sugar)' and in the cafeteria a huge 'buffet' of gummy animals. I was stunned. Sick. No wonder they are so ill. And our medical system has completely failed them. Thank you Thomas!
  • @5dimension237
    I was diagnosed with Pancreatic CA stage 4 while I was pregnant. The tumor grew in 1 month like a melon size, I changed my diet, no sugar, no carbs, plenty of purified water, potassium/magnesium, D3, Zinc, turmeric, cayenne pepper and fasting. The tumor stopped growing and MD Anderson could not understand the behavior of the tumor.
  • @emaginate1
    I have had 3 total surgeries for previous younger cancers including 2019 my new Thyroid cancer. I've bumped up my calorie restriction and I fast more and hydrate more and eliminated most carbs and all sugars except what's in fresh fruit and vegetables and I'll continue because I'm surviving my thyroid cancer. I'm age 72 and I have been genetic tested and I'm not a gene carrier of most common cancers. I also have a blood test that tells my Dr. If I have any active cancer(s) anywhere which helps me feel less anxious. I'm a fan of Dr. Seyfried and I hope he keeps talking about his ideas, which I practice. I'm trying to survive my cancer and there's an 85 % I'll survive until 2024. After that I'll continue calorie restriction fasting, infrared sauna, Kangen water hydration and prayer. 💜💜 Sincerely, Jan Stein Palm Beach, FL
  • While completing my undergraduate degree in molecular biology i worked as a valet at a world renowned cancer center in southern florida. I was always helping patients load boxes and boxes of a nutritional supplement into their cars. The nutritional label indicated that the vast majority of the product was added sugar and some protein. Some time later, while parking a patients truck i saw a paper in the passenger’s seat labeled something like “Food Guide”. One of the items listed was “chocolate milkshake from McDonalds, Burger King etc.” This lecture gave me motivation when i began studying for medical school admissions tests and i am now in my second year of medical school. I have confidence that as the older generations die off and younger physicians take their place, the work of Dr. Seyfried and others such as Dr. Dominic D’Agostino will be considered more seriously when determining patient treatment options/plan.
  • @earlj.d.6285
    For me it’s mainly the fact that numbers of cases and deaths continue to rise even after decades fighting this disease. It’s high time we start looking at the work of the “Mavericks” in cancer research and see if the modern lifestyle is the issue and what can we do ourselves to combat cancer. This video is gold
  • @msvergara
    My 80 years old brother was diagnosed with adenocarcinoma in the pancreas in April 2023. I am a not practitioner MD and when I saw this professor's explaining the metabolic approach of cancer, it made perfectly sense to me. I suggested my brother NOT to take radio nor chemotherapy and follow LCHF diet + turmeric + berberine. In August 2023 he took a new PET and the cancer was gone. His doctor couldn't believe the result of the control PET and ordered to review the biopsy from April believing there was a mistake in the biopsy report and that it has not been a Ca, but a pancreatitis. The review of the biopsy confirmed it was an adenocarcinoma. Many many thanks Dr. Seyfried 🙏
  • @bgregg55
    "There ain't no money in the cure. The money's in the medicine."
  • @edwardpf123
    This shows the power of the paradigm.  The entire paradigm regarding cancer has to change.
  • "We don't believe in feeding dogs raw meat" That line is a great clue on what is going on with our society. Even the fact that we make some parts of nature illegal and call it "protection".
  • @raulandmylulu
    I’ve watched my family members die off from an early age. Mother Colon cancer: age 54 brother colon cancer: age 47 Father intestinal cancer:age 69. I am 54, my mothers age when she passed. Sadly waiting for my turn. NO. Not today. Ketones are my super hero. This is absolutely the silver bullet . Thank you Doc.
  • @deanmindock3680
    He deserves to be listened to very carefully. He is revealing a lot to help us. Also shows how the cancer industry isn't going to change their system. It is all about money and treating cancer with expensive therapies that fail at a very high rate, like 97% of the time. His therapies do no damage, improve wellbeing, and give a patient a good shot at complete recovery. We should all get on to a diet that he prescribes. The Ketogenic Diet, restricted in calories. Give the body all the nutrients it needs but without excess calories. The Ketogenic Diet will greatly reduce the odds for getting any of the chronic diseases and should add a lot of quality years to your life.
  • @bjsandusky9848
    first time I walked into a chemo clinic, they offered me candy out of a bowl of candy bars...which was all over the clinic...I was so shocked...fortunately, tests showed the cancer I had was too slow growing to respond to chemo....Praise God!!!
  • @bretmoura9540
    This man is a genius and will go down in history as a pioneer in the advancement of cancer research and treatment.
  • @abinicoarts4576
    Years ago I had an old cat develop cancer. Switched diet from processed nuggets to raw food - turkey meat with supplements, and about twice a week a raw chicken wing or thigh. Cat lived another 6 years - was probably around 22 when he passed away. BTW the supplements were NuVet and Nu Pro - good stuff, even for a healthy cat.
  • @roblanchi5159
    Thank you. I was fighting with my prostate cancer oncologist not to send me to 48 sections of highly toxic radiation. he said" there is no other way" He was wrong.