17.5y Younger Biological Age (Blood Test #4 In 2024, Full Lab Test Analysis)

I'm a Urologist . The testosterone levels are excellent and healthy. Remember there is variability of testosterone sensitivity which is why the normal range is wide.

Excellent results, Mike, congrats.

tks for the Excel link for the Levine test,very useful

Thank you

Mike -- Have you seen this preprint? Biological aging of different blood cell types 2024, Marttila et al. From what I can tell the processing of the blood spots for the epigenetic tests DunedinPACE, Horvath, etc use only peripheral blood mononuclear cells and don't include RBCs as they degrade. This papers indicates that different pbmcs have different ages even within the same person. And I'm left wondering if the ratio of the pbmc's are important (e.g. for DunedinPACE more B cells and monocytes relative to T cells gives an older age). If you have a line to trudiagnostic it might be worth asking them about the processing of cell numbers. You can get lymphocyte counts via flow cytometry, which might help you resolve things, but pricy though.

Mike, can you check for bilirubin correlations with other biomarkers or epigenetic age in a future video? I recently stumbled across some articles which suggest that higher or at least slightly higher than average bilirubin levels are associated with antioxidant and anti-inflammatory effects which protect against a wide variety of diseases, despite bilirubin being infamously known as a toxic by-product which underlies jaundice.

How often do you check TSH? Excellent on the cholesterol!

Excellent Michael, why do you think it got worse in 2023?

btw you have amazing total testosterone and your free t is great too , thats a fasted am peak level correct . anyway i am going to be interested to see what you decide to do with that sbhg

I have seen studies that indicate lower WBC can be indicative of lower inflammation

At what point do you plan using more supplements, what's the time frame and biomarker sets that'd warrant that?

I think you should put all the data you've accumulated into a machine learning model and see if it can tease out some patterns for you. A lot of work, though, exhaustively entering all that data, inputs and outputs, for only the possibility it might recognize patterns you've missed.

Are you mixing up biological (epigenetic/DNAm) age such as PhenoAge with phenotypic age? One can have vastly different phenotypic age and PhenoAge. Have you measured PhenoAge or GrimAge?

I've heard that Brazil nuts can vary quite a lot in their selenium content for various reasons. Are you able to confirm the content of yours? Would you consider supplementing briefly instead of eating the nuts to test their content?

Have you considered that youthful results might not be the best for maximum life expectancy. Could it be that when you are young, a person is like a raging campfire that burns out its vitality faster than a fading campfire burning with a small flame.

Are you still losing weight or is your weight constant now?

Do you have a video on your exersise routine?

No comments on Eusinophiles mark ?

First of all, great numbers. Your difference in BioAge - Levine phenoage is more than mine. I have many thoughts on this report of yours, since I also have Hashimoto's and do caloric restriction as well as track testosterone/shbg. 1. As I commented last time, T3 will be increased by going to maintenance/surplus, and especially if carbs are added. Adding iron/selenium/iron/zinc only helps if you are deficient which you are not. Your T3 is low due to energy deficit. Low carb diets depress T3 further compared to moderate carbs diets, even if calorie intake is same. 2. Your high SHBG is problematic. Its too high. It is independently linked to erectile dysfunction in at least one Chinese study. (Ming Liao et al 2012). SHBG is raised by caloric restriction, low carb diets, low insulin secretion, high cortisol. Or during liver disease. I predict that your fasting insulin is low (due to higher fat diet, insulin sensitivity and exercise), cortisol is highish causing the high SHBG. Eating more calories from carbs should ameliorate this issue. This type of thing is common in keto/carnivore blood numbers (one of the reasons Paul Saladino added back fruits). SHBG is also lowered by TRT. 3. Your fasting glucose at 98 is problematic. I think this again is due to high stress due to diet, caloric restriction and exercise raising cortisol. High cortisol, low insulin = higher glucose. Tldr - i think constant caloric restriction is showing its effect. Probably will do well with a break.

Curious if you've ever checked fasting insulin since lower levels can increase SHBG. Also, do you know yourA1c level?